Extending lockdowns even by a matter of weeks will "cost lives", the co-founder of fast-food chain Leon has said.
John Vincent said businesses were "at the heart of a functioning and healthy society" and were losing money that should be going to their employees and the government through taxes.
The prime minister has said
people should be "optimistic but patient" about national lockdowns.
He will set out a road map for lifting England's restrictions on Monday.
Speaking on BBC Radio 4's Today programme, Mr Vincent said it was "quite possible" that Leon could fold "if weeks and months drag on", as it was losing around £200,000 a week. That figure was more like £800,000 when "what we would have been making" is taken into account, he said.
"That's money that isn't going into the economy, it's not going into the wallets of the people who work for Leon, and it's not going to pay the taxes that we need to pay," he said.
"No one's asked us for these numbers, so how does the government know what's going on in the economy?"
He said there had been a "pantomime of scientists against business" during the pandemic - "as if there isn't one giant shared agenda" - and the latter were "positioned as the uncompassionate ones".
But the length of lockdowns "matters hugely", he said, adding that the government had not produced a "holistic cost-benefit analysis".
"Therefore, how can we be making this decision about the impacts on the young today and for their futures? How can we make (decisions about) the impacts of the huge economic destruction which is costing lives? When we lose our economy we lose lives," he said.
"How can we be saying, glibly, 'it doesn't matter if lockdown carries on for a few weeks or months longer than necessary' without the analysis? I wouldn't launch a chicken wrap without analysis."
The prime minister said during a coronavirus briefing this week that
steps taken to ease lockdown should be "cautious but irreversible".
Mr Johnson hailed the success of the vaccine rollout, but warned the threat from the virus remained "very real" and now was not the time to "relax".