The vast majority of people travelling into Euston continue their journeys by changing to Tube or bus. So changing at Old Oak Common instead of Euston isn't a great issue. It's only an issue if / when the journey involves multiple changes of transport modes.
I suspect that this is true for some people, but not for most. It would need a comprehensive analysis of journey patterns, available transport links (both current and planned at OOC) and journey times to understand this.
Just thinking about some of the key destinations for people arriving from the Midlands / North at either Euston or OOC, my back of a fag packet analysis is as follow:
- West End of London for nightlife (e.g. Leicester Sq) - Euston is better but Elizabeth Line goes to Tott Ct Road which is reasonably handy
- Bloomsbury for the tourist hotels - Euston is walking distance
- Whitehall / Westminster for government offices - Euston is much better, tube to either Charing X or Victoria. Would require an extra change from OOC
- City (Bank / Moorgate) - both will be on a direct service
- Canary Wharf - OOC will be direct on Elizabeth Line, Euston requires a change at Bank onto DLR or London Bridge onto Jubilee Line
- Heathrow - OOC is better
- Gatwick - slightly longer from OOC but both require a change (or a walk at Euston, to pick up Thameslink at KXStP)
- other mainline terminals - Euston is better connected
So I'd say for the majority of journey types, Euston is noticeably better.